Patent Issued Covering AbGenomics' Invention

An Australian patent 2002305041 has issued on February 24, 2006 covering AbGenomics' invention "Modulators of P-Selectin Glycoprotein Ligand 1". The invention is directed to the compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

Patent Issued Covering AbGenomics' Invention

A N.Z. patent 531199 has issued on March 10, 2005 covering AbGenomics' invention "Modulators of P-Selectin Glycoprotein Ligand 1". The invention is directed to the compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions such as autoimmune diseases, transplant rejection, and allergic diseases.

Patent Issued Covering AbGenomics' Technology

U.S. patent 6,800,462 has issued on October 5, 2004 covering AbGenomics' technology "Production of recombinant proteins in vivo and use for generating antibodies". The invention is directed to methods of producing a protein in vivo by administering a nucleic acid encoding the protein to an animal, and of easy isolation of the said protein from biological samples of the animal. These methods allow for rapid and efficient production and isolation of a protein encoded by any nucleic acid sequence of interest and the protein, in turn, can be used to generate antibodies or for other use.

International Publication

Hsieh, K. Y., Tsai, C.C., Wu, C. H., and Lin, R. H. (2003). Epicutaneous exposure to protein antigen and food allergy. Clin. Exp. Allergy. 33 (8):1067-75.

Hsieh, K.Y., Hsu, C. I., Lin, J. Y., Tsai, C. C., and Lin, R. H. (2003) Oral administration of an edible-mushroom-derived protein inhibits the development of food-allergic reactions in mice. Clin. Exp. Allergy. 33 (11):1595-602.

Chen, S. C.; Huang, C. C.; Chien, C. L.; Jeng, C. J.; Chiang, E.; Liu, M. R.; Wu, C.H. H.; Chang, C. N.; and Lin, R. H. * (2004) Cross-Linking of P-Selectin Glycoprotein Ligand-1 Induces Death of Activated T Cells. Blood. 104 (10) : 3233-3242 .

Huang C.C., Lu Y.F., Wen S.N., Hsieh W.C., Lin Y.C., Liu M. R., Chiang E., Chang C.N. and Lin R.H. (2005) A Novel Apoptosis-inducing anti-PSGL-1 Antibody for T Cell-mediated Diseases. Eur. J. Immunol. 35: 2239-2249.